Description

Etoposide 3',4'-Quinone is a chemically modified derivative of the established anticancer agent etoposide. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a key intermediate or active metabolite in the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and advanced synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel etoposide analogs and related podophyllotoxin derivatives for anticancer research.
• Biochemical Research: Used in studies investigating the metabolism, mechanism of action, and structure-activity relationships (SAR) of etoposide and its metabolites.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, or NMR for quality control and metabolic profiling in pharmaceutical analysis.
• Anticancer Agent Development: Acts as a precursor or model compound in the development of new topoisomerase II inhibitors with potentially improved efficacy or reduced side effects.
• Academic Research: Utilized in university and institutional labs for chemical biology studies and medicinal chemistry projects targeting DNA-topoisomerase complexes.

Basic Information

Product Name	Etoposide 3',4'-Quinone
CAS No.	105016-65-7
Molecular Formula	C29H28O13
Molecular Weight	584.53 g/mol
Synonyms	Etoposide Quinone; 3',4'-Dioxoetoposide; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside], 3',4'-dione; VP-16-3',4'-quinone; 4'-Demethylepipodophyllotoxin β-D-glucopyranoside, 9-[4,6-O-ethylidene-], 3',4'-dione; NSC 358218; Etoposide metabolite quinone
EINECS	Contact for details

Quality Control

Our Etoposide 3',4'-Quinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its light-sensitive nature and propensity to be easily oxidized, prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.