Description

Osteocalcin CAS NO 104982-03-8 is a small, non-collagenous protein hormone primarily synthesized by osteoblasts and is a key biomarker for bone formation and turnover. Its significance lies in its critical role in regulating bone mineralization, energy metabolism, and endocrine functions, making it a vital compound for advanced biomedical research. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and clinical diagnostics sectors who are focused on metabolic bone diseases, diabetes research, and the development of novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on bone biology, osteoblast function, and the bone-vascular axis.
• Clinical Diagnostics: Used as a reference standard in immunoassays (e.g., ELISA) to quantify osteocalcin levels in serum for diagnosing and monitoring osteoporosis and other metabolic bone disorders.
• Pharmaceutical Development: Serves as a critical target or biomarker in drug discovery programs for osteoporosis, diabetes, and obesity.
• Endocrinology Studies: Investigation of osteocalcin's role as a hormone influencing glucose metabolism, testosterone production, and cognitive function.
• Nutraceutical & Cosmetic Research: Evaluation in formulations aimed at improving bone health or skin vitality, though primarily at the research stage.
• Academic & Institutional Labs: Essential reagent for cell culture studies, animal model research, and molecular biology experiments related to skeletal physiology.

Basic Information

Product Name	Osteocalcin
CAS No.	104982-03-8
Molecular Formula	C₁₆₄H₂₆₆N₅₀O₅₃ (Approximate, for human uncarboxylated form)
Molecular Weight	~5.8 kDa (Approximate)
Synonyms	Bone Gla Protein (BGP); Osteocalcin, human; γ-carboxyglutamic acid-containing protein; BGLAP; OC; CN; Bone γ-carboxyglutamate protein; Carboxyglutamic acid-containing protein
EINECS	Contact for details

Quality Control

Our Osteocalcin is produced under stringent conditions to ensure high biological activity and purity, suitable for sensitive research applications. Each batch is rigorously tested using advanced analytical techniques including HPLC for purity, mass spectrometry for identity confirmation, and bioactivity assays. Certificates of Analysis (COA) detailing purity, identity, and biological activity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity	Determined by suitable cell-based or binding assay
Endotoxin Level	< 1.0 EU/μg
Moisture Content (KF)	< 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.