Description

3-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid is a versatile fluorinated organic building block prized for its unique combination of a carboxylic acid handle and a lipophilic, electron-withdrawing trifluoromethyl group. This compound matters for its critical role in modulating the physicochemical properties of target molecules, enhancing metabolic stability, membrane permeability, and binding affinity in advanced chemical synthesis. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group contributes to improved bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, leveraging its ability to influence polarity and molecular alignment.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Building Block: Utilized in various coupling reactions, esterifications, and amide formations to create complex, fluorinated molecular architectures for research and development.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel chiral auxiliaries, ligands, and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	3-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid
CAS No.	104907-44-0
Molecular Formula	C₈H₁₁F₃O₂
Molecular Weight	196.17 g/mol
Synonyms	3-(Trifluoromethyl)cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 3-(trifluoromethyl)-; 3-Trifluoromethylcyclohexanecarboxylic acid; 3-Carboxy-α,α,α-trifluorotoluene, hexahydro-; 1-Carboxy-3-(trifluoromethyl)cyclohexane; Hexahydro-3-(trifluoromethyl)benzoic acid
EINECS	Contact for details

Quality Control

Our production of 3-(Trifluoromethyl)Cyclohexane-1-Carboxylic Acid adheres to stringent quality management protocols. Every batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries, ensuring reliable supply for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its carboxylic acid nature and light-sensitive property, prolonged exposure to elevated temperatures or direct light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.