Description

(S)-2-Amino-3-(3-Fluorophenyl)Propionicacidethylester CAS NO 104880-99-1 is a high-purity, non-natural amino acid derivative characterized by its chiral (S)-configuration and a fluorine-substituted aromatic side chain. This compound is a critical chiral building block in modern organic synthesis, valued for its role in introducing specific stereochemistry and fluorinated motifs into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetics & Bioactive Peptides: Used to incorporate fluorinated phenylalanine analogs into peptide chains to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Serves as a building block for developing novel herbicides and pesticides with improved efficacy and environmental profiles.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Utilized in the design of fluorinated amino acid probes for studying protein structure, function, and interactions.
• Material Science: A potential monomer or precursor for specialty polymers and advanced materials with unique optical or electronic properties.

Basic Information

Product Name	(S)-2-Amino-3-(3-Fluorophenyl)Propionicacidethylester
CAS No.	104880-99-1
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	(S)-Ethyl 2-amino-3-(3-fluorophenyl)propanoate; L-3-Fluorophenylalanine ethyl ester; (S)-3-Fluoro-DL-phenylalanine ethyl ester; Ethyl (S)-2-amino-3-(3-fluorophenyl)propionate; (S)-α-Amino-3-fluorobenzenepropanoic acid ethyl ester; F-Phe-OEt; 3-F-DL-Phe-OEt
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(3-Fluorophenyl)Propionicacidethylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.