Description

1,25,28-Trihydroxyvitamin D 2 is a biologically active metabolite of vitamin D2 (ergocalciferol). This compound is of significant interest in biochemical research and pharmaceutical development due to its role in calcium metabolism and cell regulation. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic studies, drug discovery, and the development of novel therapeutic agents targeting bone health and immune function.

Application

• Biochemical Research: Used as a high-purity reference standard and active compound in studies of vitamin D metabolism, receptor binding, and gene expression.
• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of treatments for osteoporosis, renal osteodystrophy, and psoriasis.
• Cell Culture Studies: Employed in in vitro assays to investigate its effects on cell differentiation, proliferation, and immune modulation.
• Analytical Standard: Essential for the calibration of analytical equipment (e.g., HPLC, LC-MS) to ensure accurate quantification of vitamin D metabolites in various matrices.
• Nutraceutical Research: Investigated for potential applications in advanced dietary supplements targeting specific metabolic pathways.

Basic Information

Product Name	1,25,28-Trihydroxyvitamin D 2
CAS No.	104870-37-3
Molecular Formula	C28H44O5
Molecular Weight	460.65 g/mol
Synonyms	1α,25,28-Trihydroxyergocalciferol; 1α,25,28-Trihydroxyvitamin D2; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; 1,25,28-TriOH D2
EINECS	Contact for details

Quality Control

Our 1,25,28-Trihydroxyvitamin D 2 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term stability, the product should be kept in a freezer. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.