Description

n-Methoxy-n-Methyltrifluoroacetamide is a versatile and highly reactive trifluoroacetylating reagent, primarily used as a key intermediate in the synthesis of complex organic molecules. Its value lies in its ability to efficiently introduce the trifluoroacetyl group, a moiety critical for modulating the biological activity, metabolic stability, and physicochemical properties of target compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors, where precise fluorination is required.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring trifluoroacetyl-protected amines or amides.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine atoms enhance efficacy and environmental persistence.
• Peptide Chemistry: Serves as a reagent for the selective trifluoroacetylation of amino groups during peptide synthesis and modification.
• Material Science: Employed in the creation of specialty polymers and coatings that benefit from the unique properties imparted by fluorine-containing segments.
• Organic Synthesis Reagent: Acts as a versatile reagent for the preparation of trifluoroacetamides, ketones, and other fluorinated compounds in research laboratories.
• Ligand and Catalyst Development: Used to synthesize fluorinated ligands for metal complexes and catalysts used in asymmetric synthesis.

Basic Information

Product Name	n-Methoxy-n-Methyltrifluoroacetamide
CAS No.	104863-67-4
Molecular Formula	C5H8F3NO2
Molecular Weight	171.12 g/mol
Synonyms	N-Methoxy-N-methyl-2,2,2-trifluoroacetamide; N-Methoxy-N-methyltrifluoroacetamide; N-Methyl-N-methoxytrifluoroacetamide; Trifluoroacetic acid N-methoxy-N-methylamide; N-Methoxy-N-methyl-2,2,2-trifluoroacetamide; Weinreb trifluoroacetamide; TFA-N(OMe)Me
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methyltrifluoroacetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of the pharmaceutical and fine chemical industries. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.