Description

n-Des(Cyclohexylaminocarbonyl)-n-Acetyl Glipizide is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of significant value in the pharmaceutical industry for its role in the synthesis and analytical characterization of related sulfonylurea derivatives. It is primarily required by research institutions, analytical laboratories, and manufacturers engaged in the production of diabetes management therapeutics and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for advanced sulfonylurea-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used in Quality Control (QC) and Research & Development (R&D) laboratories for method development, validation, and impurity profiling via HPLC, LC-MS, and other chromatographic techniques.
• Metabolite Studies: Serves as a relevant compound for pharmacokinetic and metabolic pathway research related to glipizide and analogous therapeutics.
• Process Chemistry & Scale-Up: Employed in optimizing manufacturing processes for diabetes drugs, ensuring consistency and purity during commercial production.
• Academic & Contract Research: Utilized in university and CRO settings for medicinal chemistry projects and investigating structure-activity relationships (SAR).

Basic Information

Product Name	n-Des(Cyclohexylaminocarbonyl)-n-Acetyl Glipizide
CAS No.	104838-12-2
Molecular Formula	C21H25N3O5S
Molecular Weight	431.51 g/mol
Synonyms	1-Cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea N-Acetyl Derivative; N-Acetyl Descyclohexyl Glipizide; Glipizide Impurity; Glipizide Related Compound; 5-Methyl-N-[2-[4-[[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-pyrazinecarboxamide N-Acetyl Derivative; Des(Cyclohexylaminocarbonyl) Acetyl Glipizide
EINECS	Contact for details

Quality Control

Our n-Des(Cyclohexylaminocarbonyl)-n-Acetyl Glipizide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.