Description

n-(4-(3-Chlorodiazirin-3-Yl)Benzoyl)Glycine is a specialized diazirine-based chemical building block, primarily valued for its photoreactive properties. This compound is essential for advanced biochemical research and pharmaceutical development, enabling precise photoaffinity labeling and cross-linking studies. It is a critical reagent for researchers and manufacturers in proteomics, drug discovery, and materials science who require high-purity, functionalized intermediates for probing molecular interactions.

Application

• Photoaffinity Labeling Probes: Acts as a key photoreactive moiety for creating probes to study protein-ligand interactions and identify binding sites.
• Cross-linking Reagent: Used in biochemical research to covalently cross-link biomolecules upon UV light activation for structural analysis.
• Proteomics Research: Incorporated into molecules to capture and identify transient or weak protein complexes.
• Drug Discovery Platforms: Serves as a versatile intermediate in the synthesis of potential therapeutic agents that require targeted covalent binding.
• Bioconjugation Chemistry: Utilized for attaching various labels, tags, or drugs to biological molecules in a light-controlled manner.
• Materials Surface Functionalization: Applied in surface science to create photoreactive coatings or modify material interfaces.

Basic Information

Product Name	n-(4-(3-Chlorodiazirin-3-Yl)Benzoyl)Glycine
CAS No.	104745-67-7
Molecular Formula	C11H9ClN4O3
Molecular Weight	280.67 g/mol
Synonyms	Glycine, N-[4-(3-chloro-3H-diazirin-3-yl)benzoyl]-; 3-Chloro-3-[4-(carboxymethylcarbamoyl)phenyl]diazirine; (4-(3-Chlorodiazirin-3-yl)benzoyl)glycine; 4-(3-Chloro-3H-diazirin-3-yl)benzoic acid glycine amide; Photoaffinity Labeling Reagent; Diazirine-Benzoyl-Glycine derivative; CLDZ-Bz-Gly-OH; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our n-(4-(3-Chlorodiazirin-3-Yl)Benzoyl)Glycine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.