Description

Boc-D-Glu(OtBu)-OH is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide sequences while preventing unwanted side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-glutamic acid into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins requiring high coupling efficiency.
• Pharmaceutical Research & Development: Serves as a building block for creating peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic or therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships.
• Biochemical Research: Used in the study of enzyme-substrate interactions and the synthesis of custom peptide substrates or inhibitors.

Basic Information

Product Name	Boc-D-Glu(OtBu)-OH
CAS No.	104719-63-3
Molecular Formula	C₁₄H₂₅NO₆
Molecular Weight	303.35 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-glutamic acid 5-tert-butyl ester; (R)-2-((tert-Butoxycarbonyl)amino)pentanedioic acid 5-tert-butyl ester; Boc-D-Glu(OtBu)-OH; Boc-D-glutamic acid 5-tert-butyl ester; D-Glutamic acid, N-(1,1-dimethylethoxy)carbonyl-, 5-(1,1-dimethylethyl) ester; Boc-D-Glu(OtBu); N-Boc-D-glutamic acid 5-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Glu(OtBu)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.