Description

Pro-Osteocalcin CAS NO 104645-98-9 is a synthetic peptide fragment corresponding to the N-terminal region of the human osteocalcin protein, a key non-collagenous protein found in bone. This high-purity reference standard is critical for research and development in bone metabolism and endocrinology. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostic manufacturers, and academic researchers focused on osteoporosis, diabetes, and metabolic bone diseases.

Application

• Biomarker Research & Assay Development: Serves as a critical reference standard and calibrator in the development and validation of immunoassays (ELISA, RIA) for measuring osteocalcin levels in biological samples.
• Pharmaceutical R&D: Used in preclinical studies to investigate bone formation, the bone-vascular axis, and the role of osteocalcin in glucose metabolism and energy expenditure for novel therapeutic targets.
• Clinical Diagnostics: Essential for the quality control and standardization of commercial diagnostic kits used to assess bone turnover and monitor conditions like osteoporosis, Paget's disease, and renal osteodystrophy.
• Academic & Biomedical Research: A key tool for studying osteoblast activity, bone mineralization processes, and the cross-talk between bone and other organ systems like pancreas and muscle.
• Peptide Chemistry & Conjugation: Acts as a starting material or hapten for the production of specific antibodies, or for conjugation in various biochemical and histological applications.

Basic Information

Product Name	Pro-Osteocalcin
CAS No.	104645-98-9
Molecular Formula	C44H68N12O15
Molecular Weight	981.1 g/mol
Synonyms	Human Osteocalcin (1-19); N-Terminal Osteocalcin Fragment; N-MID Osteocalcin; Gla-Osteocalcin (1-19); Bone Gla Protein Fragment (1-19); BGP (1-19); OC (1-19); HOC (1-19); γ-Carboxyglutamic Acid-containing Osteocalcin Peptide
EINECS	Contact for details

Quality Control

Our Pro-Osteocalcin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and detailed Certificates of Analysis (COA) with every shipment to ensure compliance with research and diagnostic industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.