Description

5-Chloro-2,4-Difluoro-6-Methoxyisophthalonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its unique halogen and methoxy substitution pattern. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its specific substitution enables precise molecular tuning. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic systems and functional dyes.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of novel drug candidates, particularly in kinase inhibitor and antimicrobial research.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and fungicides with enhanced activity and selectivity.
• Organic Electronic Materials: Used in the research and development of organic semiconductors, OLED (Organic Light-Emitting Diode) materials, and non-linear optical (NLO) chromophores.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Functional Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes for imaging, sensors, and high-performance pigments.
• Cross-Coupling Reactions: A valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to its halogen substituents.

Basic Information

Product Name	5-Chloro-2,4-Difluoro-6-Methoxyisophthalonitrile
CAS No.	104581-68-2
Molecular Formula	C9H3ClF2N2O
Molecular Weight	228.58 g/mol
Synonyms	2,4-Difluoro-5-chloro-6-methoxyisophthalonitrile; 5-Chloro-2,4-difluoro-6-methoxybenzene-1,3-dicarbonitrile; 1,3-Dicyano-2,4-difluoro-5-chloro-6-methoxybenzene; Isophthalonitrile, 5-chloro-2,4-difluoro-6-methoxy-; 104581-68-2; 5-Chloro-2,4-difluoro-6-methoxy-1,3-benzenedicarbonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Difluoro-6-Methoxyisophthalonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.