Description

Substance P (5-11), n-α-(Desamino-3-Iodotyrosyl)-8-n-Me-Phe-5,6-Asp- is a specific, iodinated fragment analog of the neuropeptide Substance P. This compound matters as a critical research tool in neuroscience and pharmacology, primarily used to study the structure-activity relationships of neurokinin receptors, particularly the NK1 receptor. It is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on neurobiology, pain management, and inflammatory pathways.

Application

• Neuroscience Research: A key ligand for investigating the binding affinity and signaling mechanisms of Substance P at its receptor sites.
• Pharmacological Studies: Used in in vitro and in vivo assays to evaluate potential antagonists and modulators of neurokinin pathways.
• Biochemical Tool: Employed in receptor autoradiography and competitive binding experiments to map receptor distribution.
• Drug Discovery & Development: Serves as a reference standard and probe compound in high-throughput screening for novel analgesics and anti-inflammatory agents.
• Academic Research: Fundamental for university labs studying peptide hormone function, nociception, and neurogenic inflammation.
• Biomarker Research: Potential use in developing assays related to neuroinflammatory conditions.

Basic Information

Product Name	Substance P (5-11), n-α-(Desamino-3-Iodotyrosyl)-8-n-Me-Phe-5,6-Asp-
CAS No.	104499-96-9
Molecular Formula	C46H61IN8O12
Molecular Weight	1045.93 g/mol
Synonyms	Substance P (5-11), [Tyr8, I-Tyr3]-; [Tyr8, I-Tyr3]-Substance P (5-11); [Tyr8, 3-I-Tyr3]-Substance P (5-11); [Tyr8, 3-Iodo-Tyr3]-Substance P (5-11); n-α-(Desamino-3-Iodotyrosyl)-8-n-Methyl-Phenylalanine-5,6-Aspartic Acid Substance P (5-11); SP (5-11), [Tyr8, I-Tyr3]-; Neurokinin receptor ligand fragment
EINECS	Contact for details

Quality Control

Our Substance P (5-11) fragment analog is produced under strict quality management systems suitable for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure reproducibility and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep under inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.