Description

(3R,4R)-(+)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine Hydrochloride is a high-value chiral bisphosphine ligand, specifically the hydrochloride salt of the well-known Benzyl-Pyrrolidine Bisphosphine (BenzP*) ligand. This compound matters as a critical catalyst component in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals with high selectivity and yield. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity chiral auxiliaries for hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Rhodium and Ruthenium Complex Formation: Used to prepare highly active chiral transition metal catalysts for C-C and C-X bond formation.
• Pharmaceutical Process Development: Critical for the scalable synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Facilitates the creation of chiral building blocks and specialty aroma chemicals.
• Academic and Industrial R&D: A staple reagent in methodology development for new asymmetric transformations.
• Ligand Screening Libraries: Included in kits for high-throughput screening to identify optimal catalytic systems.

Basic Information

Product Name	(3R,4R)-(+)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine Hydrochloride
CAS No.	104351-43-1
Molecular Formula	C39H37ClNP2
Molecular Weight	624.12 g/mol
Synonyms	(3R,4R)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine hydrochloride; BenzP* hydrochloride; (R,R)-BenzP*·HCl; (3R,4R)-(+)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine HCl; (R,R)-1-Benzyl-2,5-bis(diphenylphosphino)pyrrolidine hydrochloride; (R,R)-Benzyl Pyrrolidine Bisphosphine Hydrochloride; (3R,4R)-1-Benzyl-3,4-bis(diphenylphosphanyl)pyrrolidinium chloride
EINECS	Contact for details

Quality Control

Our (3R,4R)-(+)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to maintain stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; containers must be sealed immediately after use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.