Description

8-Demethyl-8-Hydroxy-5-Deaza-5-Carba-FMN is a synthetic, structurally modified analog of the essential enzyme cofactor flavin mononucleotide (FMN). This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a mechanism-based inhibitor and a tool for studying flavin-dependent enzymes. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in enzymology, drug discovery, and the development of novel therapeutic agents targeting specific metabolic pathways.

Application

• Enzyme Mechanism Studies: As a potent inhibitor of flavin-dependent enzymes, particularly methylenetetrahydrofolate reductase (MTHFR), for probing reaction mechanisms and active site architecture.
• Biochemical Research Reagent: Used in academic and industrial laboratories to investigate folate metabolism, one-carbon transfer pathways, and related cellular processes.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the research and development of novel anticancer and antimicrobial agents that target folate metabolism.
• Diagnostic Assay Development: Potential use in the formulation of diagnostic kits and assays designed to measure enzyme activity or screen for inhibitors in high-throughput settings.
• Metabolic Pathway Analysis: A critical tool for studying the biochemical consequences of modulating specific enzymatic steps within crucial metabolic networks.

Basic Information

Product Name	8-Demethyl-8-Hydroxy-5-Deaza-5-Carba-FMN
CAS No.	104324-32-5
Molecular Formula	C16H19N4O9P
Molecular Weight	442.32 g/mol
Synonyms	8-Demethyl-8-hydroxy-5-deaza-5-carba-riboflavin 5'-phosphate; 5-Deaza-5-carba-FMN; 8-Hydroxy-5-deaza-5-carba-FMN; 8-OH-5-deaza-5-carba-FMN; 8-Demethyl-8-OH-5-deaza-5-carba-FMN; 5-Carba-5-deazaflavin mononucleotide; 8-Hydroxy-5-carba-5-deaza-FMN; Lometrexol intermediate analog
EINECS	Contact for details

Quality Control

Our 8-Demethyl-8-Hydroxy-5-Deaza-5-Carba-FMN is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.