Description

(2E)-3-[3-(Trifluoromethyl)Phenyl]-2-Propenoic Acid Methyl Ester is a high-purity trifluoromethyl-substituted cinnamic acid derivative, a crucial building block in advanced organic synthesis. Its core value lies in its unique molecular structure, which incorporates a reactive α,β-unsaturated ester and a trifluoromethyl group, enabling the synthesis of complex molecules with enhanced properties. This intermediate is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in therapeutic areas targeting CNS disorders and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for creating fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for methodology development in cross-coupling reactions and fluorochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fine chemicals and complex target molecules on a commercial scale.

Basic Information

Product Name	(2E)-3-[3-(Trifluoromethyl)Phenyl]-2-Propenoic Acid Methyl Ester
CAS No.	104201-66-3
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	Methyl (E)-3-[3-(Trifluoromethyl)phenyl]acrylate; Methyl (E)-3-(3-Trifluoromethylphenyl)propenoate; (E)-Methyl 3-(3-(Trifluoromethyl)phenyl)acrylate; trans-3-(3-Trifluoromethylphenyl)acrylic Acid Methyl Ester; 3-(3-Trifluoromethylphenyl)-2-propenoic Acid Methyl Ester, (2E)-; α,β-Unsaturated Ester of 3-Trifluoromethylcinnamic Acid; Trifluoromethyl Cinnamate Methyl Ester
EINECS	Contact for details

Quality Control

Our (2E)-3-[3-(Trifluoromethyl)Phenyl]-2-Propenoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistent isomeric composition. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 99:1 (E/Z)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.