Description

Boc-D-Asn-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-tert-butoxycarbonyl-D-asparagine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of the D-asparagine residue into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of D-asparagine in automated and manual peptide synthesis.
• Pharmaceutical Intermediates: Used in the research and development of peptide drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as an activated ester for labeling proteins or other biomolecules with peptide sequences.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening of bioactive peptides.
• Academic & Industrial Research: Fundamental tool for studying peptide structure-activity relationships and developing new synthetic methodologies.
• Production of Chiral Compounds: Utilized in the synthesis of non-natural amino acids and complex chiral molecules.

Basic Information

Product Name	Boc-D-Asn-Onp
CAS No.	104199-82-8
Molecular Formula	C₁₅H₁₉N₃O₇
Molecular Weight	353.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-asparagine 4-nitrophenyl ester; Boc-D-asparagine p-nitrophenyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-carbamoylpropanoic acid 4-nitrophenyl ester; Boc-D-Asparagine-ONp; Boc-D-Asn-ONp; N-Boc-D-asparagine p-nitrophenol ester; D-Boc-Asn-ONp
EINECS	Contact for details

Quality Control

Our Boc-D-Asn-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity ([α]D)	≥ 99.0% ee
Melting Point	Specification available upon request
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.