Description

4-Bromo-2,6-Difluoroanisole is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and the construction of complex molecular architectures. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly those containing difluoromethoxy or related motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the bromo and fluoro substituents confer specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers and liquid crystals, leveraging its halogenated anisole structure.
• Fluorine Chemistry Studies: An essential reagent for investigating nucleophilic aromatic substitution (SNAr) and other reactions specific to fluorinated arenes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule construction.

Basic Information

Product Name	4-Bromo-2,6-Difluoroanisole
CAS No.	104197-14-0
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-3,5-difluoro-4-methoxybenzene; 2,6-Difluoro-4-bromoanisole; 4-Bromo-2,6-difluoromethoxybenzene; Anisole, 4-bromo-2,6-difluoro-; Benzene, 1-bromo-3,5-difluoro-4-methoxy-; 3,5-Difluoro-4-methoxybromobenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,6-Difluoroanisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.