Description

(1R)-Epi-Ramipril CAS NO 104195-90-6 is a high-purity stereoisomer of the well-known ACE inhibitor, Ramipril. This compound is of significant value as a critical reference standard and an advanced pharmaceutical intermediate in the research and development of cardiovascular drugs. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for method development, quality control, and process optimization.

Application

• Primary use as a certified Reference Standard for analytical method development and validation in pharmaceutical quality control laboratories.
• Critical Pharmaceutical Intermediate in the synthesis and research of novel ACE inhibitor drugs and their metabolites.
• Essential material for Impurity Profiling and identification studies to ensure the purity and safety of Ramipril-based drug products.
• Used in Pharmacological Research to study the structure-activity relationships (SAR) and stereospecific effects of ACE inhibitors.
• Key component in Stability Testing programs to understand the degradation pathways of cardiovascular APIs.
• Serves as a starting material or building block in Process Chemistry for scaling up the production of specialized pharmaceutical compounds.

Basic Information

Product Name	(1R)-Epi-Ramipril
CAS No.	104195-90-6
Molecular Formula	C23H32N2O5
Molecular Weight	416.52 g/mol
Synonyms	(1R)-Epi-Ramipril; (1R)-Ramipril Epimer; (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid; Ramipril Impurity F; Ramipril Related Compound F; (1R,3S,5S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]-2-azabicyclo[3.3.0]octane-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (1R)-Epi-Ramipril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.