Description

2-Acetylthiamine Pyrophosphate is a chemically modified, biologically active derivative of thiamine pyrophosphate (TPP), the active coenzyme form of Vitamin B1. This compound is valued for its enhanced stability and potential as a research tool in studying thiamine-dependent enzymatic processes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and biochemical research sectors for applications requiring a stabilized form of this essential cofactor.

Application

• Biochemical Research: Used as a stabilized substrate or cofactor analog in enzymatic studies of transketolase, pyruvate dehydrogenase, and other thiamine-dependent enzymes.
• Pharmaceutical Intermediates: Serves as a key intermediate in the synthesis of advanced thiamine derivatives and prodrugs for therapeutic development.
• Nutraceutical Formulation: Investigated for use in specialized nutritional supplements targeting cellular energy metabolism pathways.
• Diagnostic Reagents: Potential component in diagnostic kits and assays designed to measure thiamine status or related enzymatic activity.
• Metabolic Pathway Analysis: A tool for probing and modulating metabolic flux in cell culture and in vitro systems, particularly in carbohydrate metabolism.
• Enzyme Stabilization Studies: Employed to study the effects of cofactor modification on enzyme kinetics, stability, and mechanism.

Basic Information

Product Name	2-Acetylthiamine Pyrophosphate
CAS No.	104114-88-7
Molecular Formula	C14H21N4O7P2S
Molecular Weight	466.34 g/mol
Synonyms	Acetyl Thiamine Pyrophosphate; 2-Acetyl TPP; O-Acetylthiamine Pyrophosphate; Acetylated Cocarboxylase; 2-Acetylthiamin Pyrophosphate; Thiamine Pyrophosphate 2-Acetate; Acetyl Diphosphothiamine; 2-Acetylthiamin Diphosphate
EINECS	Contact for details

Quality Control

Our 2-Acetylthiamine Pyrophosphate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.