Description

Fmoc-D-Glutamic Acid γ-tert-Butyl Ester is a high-purity, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of D-glutamic acid residues into peptide chains, enabling the research and development of novel therapeutic peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and CROs specializing in peptide-based drug discovery and custom synthesis services.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated synthesis of complex peptides containing D-glutamic acid.
• Pharmaceutical Research: Used in the development of peptide-based active pharmaceutical ingredients (APIs), hormone analogs, and diagnostic agents.
• Peptidomimetic Design: Serves as a chiral scaffold for creating modified peptides with enhanced stability, bioavailability, or receptor specificity.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Linker Chemistry: The protected γ-carboxyl group and Fmoc-protected α-amine allow for selective deprotection and conjugation strategies.
• Academic & Institutional Research: Employed in biochemical and medicinal chemistry studies investigating protein-protein interactions and enzyme inhibitors.

Basic Information

Product Name	Fmoc-D-Glutamic Acid γ-tert-Butyl Ester
CAS No.	104091-08-9
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-D-Glu(OtBu)-OH; (2R)-5-tert-Butoxy-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]-5-oxopentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-glutamic acid 5-tert-butyl ester; Fmoc-D-Glutamic acid 5-tert-butyl ester; Fmoc-D-Glu(OtBu)-OH; N-Fmoc-D-glutamic acid γ-tert-butyl ester; D-Fmoc-Glutamic Acid γ-t-Butyl Ester; N-α-Fmoc-D-glutamic acid γ-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Glutamic Acid γ-tert-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in DMF, DMSO, dichloromethane; slightly soluble in ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.