Description

Boc-Aib-Osu CAS NO 104055-39-2 is a high-purity, protected amino acid derivative, specifically N-(tert-Butoxycarbonyl)-2-aminoisobutyric acid N-hydroxysuccinimide ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and selective incorporation of the sterically hindered 2-aminoisobutyric acid (Aib) residue into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, antimicrobial peptides (AMPs), and peptidomimetics where Aib is used to induce specific helical conformations and enhance metabolic stability.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated synthesis of complex peptides containing Aib, a non-proteinogenic amino acid known to induce 310-helical structures.
• Pharmaceutical R&D: Used in the development of peptide-based drugs, including antimicrobial agents, hormone analogs, and diagnostic peptides, where Aib incorporation improves bioavailability and proteolytic resistance.
• Peptidomimetic Design: Facilitates the creation of stabilized peptide mimics for drug discovery programs targeting GPCRs, ion channels, and protein-protein interactions.
• Bioconjugation: Serves as an active ester for coupling the Boc-Aib moiety to other molecules, amines, or solid supports under mild conditions.
• Academic & Contract Research: A fundamental reagent for university laboratories and CROs studying peptide structure, folding, and function.

Basic Information

Product Name	Boc-Aib-Osu
CAS No.	104055-39-2
Molecular Formula	C14H22N2O6
Molecular Weight	314.34 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-2-aminoisobutyric acid N-hydroxysuccinimide ester; N-Boc-2-aminoisobutyric acid succinimidyl ester; N-Boc-Aib-OSu; N-(tert-Butoxycarbonyl)-α-aminoisobutyryloxysuccinimide; Boc-Amino-isobutyric acid OS ester; Boc-Aib-OSu; tert-Butyloxycarbonyl-2-aminoisobutyric acid N-oxysuccinimide ester; Nα-Boc-α-aminoisobutyric acid N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-Aib-Osu is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory standards for research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.