Description

(D-Phe2)-Vip (Human, Bovine, Porcine, Rat) CAS NO 104051-15-2 is a synthetic peptide analog of Vasoactive Intestinal Peptide (VIP), engineered with a D-amino acid substitution at the second phenylalanine position to enhance its metabolic stability. This modification is critical for research applications requiring prolonged biological activity and resistance to enzymatic degradation. It is an essential biochemical tool for researchers in pharmacology, neurobiology, and endocrinology, facilitating studies on VIP receptor interactions, signal transduction pathways, and the development of novel therapeutic agents.

Application

• Biomedical Research: Used as a stable reference standard and probe for investigating the physiological roles and mechanisms of Vasoactive Intestinal Peptide (VIP) across multiple species.
• Drug Discovery: Serves as a key intermediate or lead compound in the development of VIP receptor agonists/antagonists for treating inflammatory, neurological, and cardiovascular conditions.
• Receptor Binding Assays: Employed in competitive binding studies to characterize VIP receptor subtypes (VPAC1, VPAC2) and determine binding affinities.
• Signal Transduction Studies: Utilized to study downstream cellular signaling cascades, including cAMP production, activated by VIP receptor engagement.
• In vitro & Ex vivo Models: Applied in cell-based assays and tissue preparations to study VIP's effects on smooth muscle relaxation, immune modulation, and neuroprotection.
• Metabolic Stability Profiling: Acts as a model compound to study the impact of D-amino acid substitutions on peptide stability and pharmacokinetics.

Basic Information

Item	Detail
Product Name	(D-Phe2)-Vip (Human, Bovine, Porcine, Rat)
CAS No.	104051-15-2
Molecular Formula	C147H238N44O43S
Molecular Weight	3327.8 g/mol
Synonyms	(D-Phenylalanine2)-VIP; VIP (1-28), (D-Phe2)-; D-Phe2-Vasoactive Intestinal Peptide; Vasoactive Intestinal Polypeptide (D-Phe2) analog; (D-Phe2)-VIP, human; VIP antagonist analog; [D-Phe2]VIP
EINECS	Contact for details

Quality Control

Our (D-Phe2)-VIP is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all quality parameters. Our quality commitment aligns with standards expected for pharmaceutical-grade peptide intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.