Description

Calmodulin Binding Peptide 1 is a synthetic peptide specifically designed to bind with high affinity and selectivity to the ubiquitous calcium-modulated protein, calmodulin. This interaction is critical for studying and modulating a vast array of cellular signaling pathways, including muscle contraction, neurotransmitter release, and gene expression. It serves as an essential research tool for biochemists, molecular biologists, and pharmaceutical researchers investigating calcium-dependent signal transduction mechanisms and developing targeted therapeutic interventions.

Application

• Biochemical Research: Used as a specific inhibitor or modulator in in vitro assays to study calmodulin-dependent enzyme activity, such as phosphodiesterase, calcineurin, and nitric oxide synthase.
• Cellular Signaling Studies: Employed in cell culture experiments to disrupt endogenous calmodulin-protein interactions, helping to elucidate specific pathways in cell proliferation, differentiation, and apoptosis.
• Drug Discovery & Screening: Acts as a reference compound or a tool in high-throughput screening (HTS) platforms to identify novel small-molecule inhibitors of calmodulin-target interactions.
• Diagnostic Development: Utilized in the development of diagnostic assays and biosensors for detecting calmodulin activity or related pathological states.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of calmodulin-peptide complexes, providing insights into binding mechanisms.
• Teaching & Reference Standard: Serves as a high-purity reference material in academic and industrial laboratories for teaching principles of protein-peptide interactions and signal transduction.

Basic Information

Product Name	Calmodulin Binding Peptide 1
CAS No.	104041-80-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Calmodulin-binding Peptide 1; CaM-BP1; CaM Binding Peptide; M13 Peptide; Skeletal Muscle Myosin Light Chain Kinase-derived Peptide; CaMKII Inhibitory Peptide (related); Autocamtide-2-related Inhibitory Peptide (AIP); KKFNARRKLKGAILTTMLA (common sequence identifier).
EINECS	Contact for details

Quality Control

Our Calmodulin Binding Peptide 1 is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and solubility data to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or aqueous buffer
Biological Activity	Confirmed by calmodulin-binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.