Description

Thioridazine n-Oxide is a significant pharmaceutical intermediate and metabolite of the antipsychotic drug Thioridazine. This compound is crucial for research and development in neuropharmacology, serving as a key reference standard and a building block for further chemical synthesis. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on neuroscience and drug metabolism studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of Thioridazine and its metabolites in biological matrices and pharmaceutical formulations.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, pharmacokinetic profiles, and bioavailability of Thioridazine in preclinical and clinical research.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic precursor in the manufacturing and process development of Thioridazine and related phenothiazine derivatives.
• Analytical Method Development: Employed for calibrating equipment and validating analytical methods such as HPLC, LC-MS, and GC-MS in quality control laboratories.
• Neuroscience Research: Used in biochemical assays and receptor-binding studies to investigate the mechanisms of action and side-effect profiles of antipsychotic drugs.
• Impurity Standard: Acts as a specified impurity standard to monitor and control the quality of Thioridazine API batches according to ICH guidelines.

Basic Information

Product Name	Thioridazine n-Oxide
CAS No.	103827-30-1
Molecular Formula	C21H26N2OS2
Molecular Weight	386.57 g/mol
Synonyms	Thioridazine N-Oxide; Thioridazine Sulfoxide; 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine 5-oxide; 2-Methylmercapto-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine-5-oxide; Mellaril Sulfoxide; TP 21 N-Oxide
EINECS	Contact for details

Quality Control

Our Thioridazine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing purity (typically ≥95% by HPLC), identity confirmation (by IR, NMR), and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.