Description

11-Desethyl Irinotecan is a key pharmaceutical intermediate and metabolite of the topoisomerase I inhibitor, Irinotecan. This compound is of significant importance for research and development in oncology, particularly in the study of drug metabolism, pharmacokinetics, and the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cancer drug discovery and bioanalytical method development.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of Irinotecan and related camptothecin analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for quantifying drug metabolites in biological matrices.
• Pharmacokinetic & Metabolism Research: Essential for investigating the metabolic pathways, clearance, and efficacy of Irinotecan in preclinical and clinical research.
• Quality Control & Impurity Profiling: Serves as a known impurity standard in the HPLC/LC-MS analysis of Irinotecan drug substances and finished products to ensure purity and safety.
• Drug Discovery & Development: Used in structure-activity relationship (SAR) studies to design new generations of topoisomerase inhibitors with improved therapeutic profiles.

Basic Information

Product Name	11-Desethyl Irinotecan
CAS No.	103816-16-6
Molecular Formula	C32H36N4O7
Molecular Weight	588.66 g/mol
Synonyms	7-Ethyl-10-hydroxycamptothecin 11-Desethyl metabolite; SN-38 11-Desethyl; (4S)-4,11-Diethyl-4-hydroxy-9-[(4-piperidinopiperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan 11-Desethyl Metabolite; 11-Deethyl Irinotecan; CPT-11 11-Desethyl
EINECS	Contact for details

Quality Control

Our 11-Desethyl Irinotecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.