Description

Prothrombin (18-23) CAS NO 103658-53-3 is a synthetic peptide fragment corresponding to residues 18-23 of the human prothrombin protein, a key precursor in the blood coagulation cascade. This high-purity peptide is essential for biochemical research and diagnostic development, enabling precise study of thrombin generation and activity. It serves as a critical reagent for pharmaceutical R&D, clinical diagnostics, and academic research focused on hemostasis, thrombosis, and related cardiovascular pathways.

Application

• Biochemical Research: Used as a substrate or reference standard in enzymatic assays to study thrombin activation kinetics and inhibition mechanisms.
• Diagnostic Reagent Manufacturing: Incorporated into in-vitro diagnostic (IVD) kits for the quantitative measurement of prothrombin time (PT) and other coagulation parameters.
• Pharmaceutical Development: Serves as a key intermediate or reference material in the discovery and quality control of anticoagulant and procoagulant therapeutics.
• Academic Studies: Facilitates fundamental research into blood coagulation disorders, vascular biology, and the molecular basis of hemostasis.
• Quality Control Standards: Acts as a certified reference material for calibrating laboratory equipment and validating assay performance in clinical and research laboratories.

Basic Information

Product Name	Prothrombin (18-23)
CAS No.	103658-53-3
Molecular Formula	C34H56N10O10S
Molecular Weight	796.94 g/mol
Synonyms	Prothrombin Fragment 18-23; H-Arg-Thr-Val-Glu-Val-Ile-OH; Thrombin Prothrombin Fragment (18-23); Arg-Thr-Val-Glu-Val-Ile; RT 18-23; Coagulation Factor II (18-23); Prothrombin (R18-I23); Prothrombin Peptide (18-23)
EINECS	Contact for details

Quality Control

Our Prothrombin (18-23) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure it meets stringent specifications for research and diagnostic use. Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.