Description

Dynorphin A Ethylamide (1-9), Metyr(1)-Mearg(7)-Leu(8)- is a synthetic peptide fragment derived from the endogenous opioid peptide Dynorphin A. This compound is a valuable research-grade biochemical for investigating opioid receptor pharmacology and neurobiological signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in neuroscience, pain management, and addiction studies. The product, identified by CAS No. 103614-28-4, is supplied with a focus on high purity and batch-to-batch consistency for reliable experimental results.

Application

• Neuroscience Research: Used as a selective κ-opioid receptor (KOR) agonist to study receptor binding, signal transduction, and downstream effects in neuronal systems.
• Pharmacological Studies: Serves as a reference standard and active agent in vitro and in vivo models for exploring analgesia, stress responses, and mood regulation.
• Drug Discovery & Development: Acts as a key biochemical tool for screening and validating novel compounds targeting the opioid receptor family in pharmaceutical R&D.
• Academic & Clinical Research: Supports fundamental research into the role of dynorphins in pain pathways, neuropsychiatric disorders, and potential therapeutic interventions.
• Biochemical Assay Development: Employed in the development and calibration of receptor binding assays (e.g., radioligand binding) and functional cellular assays.

Basic Information

Item	Details
Product Name	Dynorphin A Ethylamide (1-9), Metyr(1)-Mearg(7)-Leu(8)-
CAS No.	103614-28-4
Molecular Formula	C55H84N16O11
Molecular Weight	1129.36 g/mol
Synonyms	Dynorphin A (1-9) ethylamide; [Met1, Arg7, Leu8]-Dynorphin A-(1-9)-ethylamide; Dynorphin A 1-9 EA; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-NH-CH2-CH3; Ethylamide of Dynorphin A(1-9); Kappa opioid receptor agonist peptide; DYN A(1-9)EA
EINECS	Contact for details

Quality Control

Every batch of Dynorphin A Ethylamide (1-9), Metyr(1)-Mearg(7)-Leu(8)- is produced and analyzed under strict quality management protocols to ensure the highest standards for research applications. Our rigorous quality testing includes multiple orthogonal methods to confirm identity, purity, and peptide content. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), molecular weight confirmation (MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Retention time and mass spectrum correspond to reference
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	1129.36 ± 2 Da (MALDI-TOF or ESI-MS)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.