Description

Dynorphin A Ethylamide (1-8), n-Methyl-Tyr(1)-4-Nitro-Phe(4)-n-Methyl-Arg(7)-Leu(8)- CAS NO 103614-23-9 is a synthetic, modified peptide analog of the endogenous opioid peptide Dynorphin A. This compound is specifically engineered for research applications, offering enhanced stability and receptor selectivity for advanced pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neurobiology, pain management, and opioid receptor signaling pathways.

Application

• Neuroscience Research: As a potent and selective κ-opioid receptor (KOR) ligand for studying receptor activation, signaling cascades, and neurophysiological effects.
• Pain Mechanism Studies: Investigation of the role of dynorphin peptides in pain modulation, chronic pain states, and the development of novel analgesic targets.
• Pharmacological Profiling: Used in in vitro and in vivo assays to characterize receptor binding affinity, agonist/antagonist activity, and functional selectivity.
• Drug Discovery & Development: Serving as a critical reference standard or tool compound in high-throughput screening (HTS) and lead optimization programs for CNS disorders.
• Biochemical Research: Study of peptide-protein interactions, signal transduction pathways, and the biochemical consequences of receptor modulation.
• Academic & Clinical Research: Fundamental research into addiction, stress responses, mood disorders, and other physiological processes mediated by the opioid system.

Basic Information

Product Name	Dynorphin A Ethylamide (1-8), n-Methyl-Tyr(1)-4-Nitro-Phe(4)-n-Methyl-Arg(7)-Leu(8)- CAS NO 103614-23-9
CAS No.	103614-23-9
Molecular Formula	C53H75N13O12
Molecular Weight	1086.3 g/mol
Synonyms	Dynorphin A (1-8) ethylamide; [N-Me-Tyr¹, 4-NO₂-Phe⁴, N-Me-Arg⁷, Leu⁸]-Dynorphin A-(1-8) ethylamide; Dynorphin A 1-8 ethylamide analog; Modified Dynorphin A peptide; κ-opioid receptor selective agonist; YGGFLRRI-NH₂ analog (modified); [Me-Tyr¹, NO₂-Phe⁴, Me-Arg⁷]-Dynorphin A (1-8) ethylamide
EINECS	Contact for details

Quality Control

Our synthetic peptide products are manufactured under strict quality management systems. Each batch of Dynorphin A Ethylamide (1-8), n-Methyl-Tyr(1)-4-Nitro-Phe(4)-n-Methyl-Arg(7)-Leu(8)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.