Description

Fmoc-n-Methyl-D-Leucine CAS NO 103478-63-3 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing a sterically hindered, N-methylated D-configured leucine residue, which enhances the metabolic stability and bioavailability of therapeutic peptides. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and production of peptide therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Incorporation of the N-methyl-D-leucine moiety helps create stable, protease-resistant peptide mimics with improved pharmacological profiles.
• Combinatorial Chemistry: Serves as a valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• API Development: A critical raw material in the development and scale-up of Active Pharmaceutical Ingredients (APIs) for clinical trials and commercial manufacturing.

Basic Information

Product Name	Fmoc-n-Methyl-D-Leucine
CAS No.	103478-63-3
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-N-Me-D-Leu-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-methylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-leucine; Fmoc-N-methyl-D-leucine; N-Fmoc-N-methyl-D-leucine; D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-; N-α-Fmoc-N-methyl-D-leucine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-D-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can support customer requirements for GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.