Description

Fmoc-N-Methyl-L-Leucine CAS NO 103478-62-2 is a high-purity, protected amino acid derivative essential for modern peptide synthesis. This compound is specifically engineered to facilitate the construction of complex peptides by providing an orthogonal protecting group strategy, crucial for solid-phase peptide synthesis (SPPS). It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block (Fmoc-amino acid) for the automated, stepwise assembly of peptides on resin.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, including those requiring N-methylated amino acids to enhance metabolic stability and membrane permeability.
• Peptidomimetic Design: Incorporation of the N-methyl-leucine moiety to create constrained analogs that mimic natural peptide structures for drug discovery.
• Bioconjugation and Probe Development: Used in the preparation of labeled peptides for diagnostic assays, imaging agents, and biochemical studies.
• Combinatorial Chemistry: A key component in libraries for high-throughput screening to identify new bioactive compounds.
• Academic Research: Essential reagent for studying protein-protein interactions, enzyme substrates, and signal transduction pathways using synthetic peptides.

Basic Information

Product Name	Fmoc-N-Methyl-L-Leucine
CAS No.	103478-62-2
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-N-Me-Leu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-leucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-4-methylpentanoic acid; Fmoc-N-methylleucine; N-Fmoc-N-methyl-L-leucine; Fmoc-N-Methylleucine; N-α-Fmoc-N-α-methyl-L-leucine
EINECS	Contact for details

Quality Control

Our Fmoc-N-Methyl-L-Leucine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.