Description

Fmoc-n-Methyl-D-Valine CAS NO 103478-58-6 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing a sterically hindered, N-methylated D-valine residue, which enhances the metabolic stability and conformational rigidity of synthetic peptides. It is an essential building block for pharmaceutical researchers and manufacturers developing novel peptide-based therapeutics, diagnostic agents, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and production of peptide drugs where N-methylation improves bioavailability and resistance to enzymatic degradation.
• Conformationally Constrained Peptides: Incorporation of D-Valine and N-methylation helps stabilize specific secondary structures like β-turns, crucial for mimicking protein-protein interactions.
• Peptidomimetics & PROTACs: Serves as a versatile scaffold in the design of peptide-like molecules and proteolysis-targeting chimeras for targeted protein degradation.
• Chemical Biology Research: Employed in the synthesis of labeled peptides, activity-based probes, and tools for studying biological pathways.
• Combinatorial Chemistry Libraries: Used to introduce structural diversity and chiral centers in high-throughput screening libraries for drug discovery.

Basic Information

Product Name	Fmoc-n-Methyl-D-Valine
CAS No.	103478-58-6
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-N-Me-D-Val-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-valine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylbutanoic acid; Fmoc-N-methyl-D-valine; N-Fmoc-N-methyl-D-valine; D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-; N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-N-methyl-D-valine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-D-Valine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.