Description

(Dl-3-Hydroxy-3-Methylglutaryl) Coenzyme A is a critical biochemical cofactor and intermediate in the mevalonate pathway, essential for isoprenoid and sterol biosynthesis. This compound matters for its role in fundamental metabolic research and as a key reagent in enzymatic assays studying cholesterol synthesis, protein prenylation, and HMG-CoA reductase activity. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on metabolic disorders, cardiovascular disease, and lipid biochemistry.

Application

• Biochemical Research: Essential substrate for in vitro studies of the mevalonate pathway and HMG-CoA reductase enzyme kinetics.
• Pharmaceutical Development: Used in screening assays for novel statin drugs and other lipid-lowering therapeutic agents.
• Enzymology: Key reagent for investigating the mechanisms of enzymes involved in isoprenoid biosynthesis.
• Metabolic Pathway Analysis: A vital tool for tracing and quantifying metabolic flux in sterol and terpenoid production.
• Diagnostic Kit Manufacturing: Incorporated into enzymatic test kits for clinical research into cholesterol metabolism.
• Academic & Industrial R&D: Fundamental for basic science and applied research in biochemistry, cell biology, and metabolic engineering.

Basic Information

Product Name	(Dl-3-Hydroxy-3-Methylglutaryl) Coenzyme A
CAS No.	103476-21-7
Molecular Formula	C₂₇H₄₄N₇O₁₉P₃S
Molecular Weight	911.66 g/mol
Synonyms	HMG-CoA; DL-Hydroxymethylglutaryl Coenzyme A; 3-Hydroxy-3-methylglutaryl CoA; (R,S)-HMG-CoA; 3-Hydroxy-3-methylglutaryl-coenzyme A; Hydroxymethylglutaryl-CoA; Coenzyme A, (3-hydroxy-3-methylglutaryl)-; HMG CoA
EINECS	Contact for details

Quality Control

Our (Dl-3-Hydroxy-3-Methylglutaryl) Coenzyme A is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.