Description

(D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin CAS NO 103412-42-6 is a highly specific, synthetic bradykinin peptide analog engineered with strategic amino acid substitutions to modulate its biological activity and stability. This compound is of significant value for advanced pharmacological research, particularly in the study of kinin receptor signaling pathways and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on cardiovascular research, inflammation, pain management, and neurobiology.

Application

• Pharmacological Research: Used as a selective tool compound for investigating the structure-activity relationships (SAR) of bradykinin B1 and B2 receptors.
• Drug Discovery: Serves as a key intermediate or reference standard in the development of peptide-based drugs targeting inflammatory and pain pathways.
• Biochemical Assays: Employed in competitive binding assays, receptor activation studies, and signal transduction experiments to understand kinin system physiology.
• Stability Studies: The modified structure, including D-amino acids and non-natural residues, makes it valuable for studying peptide stability and metabolic resistance.
• Academic Research: A critical reagent for university labs exploring the role of bradykinin in conditions like hypertension, sepsis, and neurogenic inflammation.
• Biomarker Development: Potential use in developing diagnostic assays or as a calibrator in analytical methods for kinin-related biomarkers.

Basic Information

Product Name	(D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin
CAS No.	103412-42-6
Molecular Formula	C58H78N16O12S2
Molecular Weight	1191.46 g/mol
Synonyms	Bradykinin, D-Arg0,Hyp3,[β-(2-Thienyl)-D-Ala5,8,D-Phe7]-; [D-Arg0, Hyp3, β-(2-Thienyl)-Ala5,8, D-Phe7]-Bradykinin; B 4146; HOE 414; HOE-414; Modified Bradykinin Analog; Kinin Receptor Antagonist/Agonist Research Peptide; D-Arg-Hyp-β-(2-thienyl)-Ala-Ser-D-Phe-β-(2-thienyl)-Ala-Leu-Arg (discontinued IUPAC-style name)
EINECS	Contact for details

Quality Control

Our (D-Arg0,Hyp3,β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is manufactured under strict quality systems suitable for research use. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and MS for identity confirmation, to ensure compliance with exacting specifications. A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and batch-specific information is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant in the storage environment. Aliquot into single-use vials after initial thawing to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.