Description

N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)Isophthalamide is a high-purity, non-ionic iodinated contrast agent intermediate. This compound is critical for ensuring the safety and efficacy of final pharmaceutical formulations used in diagnostic imaging. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the synthesis of advanced X-ray and CT scan contrast media.

Application

• Key Intermediate for Non-Ionic Contrast Media: Primary building block for synthesizing modern, low-osmolar iodinated contrast agents like Iopromide and Ioversol.
• Pharmaceutical R&D: Used in research and development of new diagnostic imaging agents with improved patient tolerance.
• Fine Chemical Synthesis: Serves as a specialized intermediate in multi-step organic synthesis for high-value compounds.
• Quality Control Reference Standard: Employed as an analytical standard to ensure the purity and identity of final drug products.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) producing generic or novel contrast agents.

Basic Information

Product Name	N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)Isophthalamide
CAS No.	103254-70-2
Molecular Formula	C18H24I3N3O8
Molecular Weight	807.11 g/mol
Synonyms	5-(2-Methoxyacetamido)-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iopromide Intermediate; Ioversol Intermediate; Iopromide API Intermediate; 2,4,6-Triiodo-5-(2-methoxyacetamido)-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; Non-ionic contrast agent precursor; Iohexol related compound A; Triiodinated isophthalamide derivative
EINECS	Contact for details

Quality Control

Our N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)Isophthalamide is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. We provide comprehensive analytical data to support regulatory filings. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch, ensuring traceability and compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.