Description

N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)-N1,N3-Dimethylisophthalamide is a high-purity, iodinated organic compound primarily utilized as a key intermediate in the synthesis of advanced X-ray contrast media. Its molecular structure is engineered to provide excellent water solubility and low osmolality, which are critical for patient safety and diagnostic efficacy. This compound is essential for pharmaceutical manufacturers and research institutions developing next-generation non-ionic, iso-osmolar contrast agents for enhanced medical imaging procedures such as computed tomography (CT) and angiography.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic, iodinated X-ray contrast agents like Iopromide and Ioversol.
• Contrast Media Manufacturing: Serves as a precursor in the production of low-osmolar and iso-osmolar contrast media, improving patient tolerance and reducing side effects.
• Medical Research & Development: Used in R&D laboratories for developing novel diagnostic imaging compounds and studying structure-activity relationships.
• Radiology: Indirect application in the final formulations used for vascular imaging, urography, and computed tomography (CT) scans.
• Chemical Synthesis: Acts as a specialized intermediate for organic chemists creating complex, multi-functional molecules with specific iodine content.
• Quality Control Reference Standard: Can be utilized as a high-purity reference standard for analytical methods in pharmaceutical quality assurance labs.

Basic Information

Product Name	N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)-N1,N3-Dimethylisophthalamide
CAS No.	103254-63-3
Molecular Formula	C20H28I3N3O8
Molecular Weight	835.16 g/mol
Synonyms	5-(2-Methoxyacetamido)-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N1,N3-dimethylisophthalamide; Iopromide Intermediate; Ioversol Intermediate; Iomeprol Related Compound; Non-Ionic Contrast Media Intermediate; 2,4,6-Triiodo-5-[(2-methoxyacetyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-N1,N3-dimethyl-1,3-benzenedicarboxamide; Ultravist Intermediate; Optiray Intermediate
EINECS	Contact for details

Quality Control

Our N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)-N1,N3-Dimethylisophthalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical synthesis. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Production can be aligned with cGMP (Current Good Manufacturing Practice) guidelines and relevant ICH Q7 standards upon request to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.