Description

1 N6-Ethenocoenzyme A Lithium is a chemically modified coenzyme A derivative where the N6 position of the adenine moiety is ethenylated. This compound serves as a critical biochemical tool and a stable analog for studying coenzyme A-dependent enzymatic processes, particularly those involving acyl group transfer. It is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and enzymatic assay design, providing a valuable probe for acetyltransferase and other CoA-utilizing enzyme mechanisms.

Application

• Biochemical Research: Used as a substrate analog to study the kinetics and mechanisms of CoA-dependent enzymes, such as acetyltransferases and acyl-CoA synthetases.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify and characterize novel inhibitors or activators of CoA-utilizing targets.
• Enzymology Studies: Serves as a stable, fluorescent probe (due to the etheno group) for real-time monitoring of enzymatic activity without radioactive labels.
• Metabolic Pathway Analysis: A tool for investigating lipid metabolism, histone acetylation, and other cellular processes involving CoA derivatives.
• Diagnostic Reagent Manufacturing: A key component in the formulation of specialized diagnostic kits for measuring specific enzyme activities in clinical samples.
• Academic Research: Utilized in universities and research institutes for fundamental studies on protein acylation and post-translational modifications.

Basic Information

Product Name	1 N6-Ethenocoenzyme A Lithium
CAS No.	103213-58-7
Molecular Formula	C23H36N7O16P3S·xLi
Molecular Weight	Approx. 823.46 (Free acid), Contact for exact lithium salt form.
Synonyms	1,N6-Etheno-CoA Lithium Salt; Etheno-Coenzyme A Lithium; ε-CoA Lithium; 1,N6-Ethenoadenosine Coenzyme A Lithium; N6-Etheno-CoA Li; Fluorescent CoA Analog; Acetyl-CoA Analog (Etheno); Coenzyme A Etheno Adduct Lithium Salt
EINECS	Contact for details

Quality Control

Our 1 N6-Ethenocoenzyme A Lithium is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.