Description

Guanosine 5'-Diphosphate Tris Salt is a high-purity nucleotide derivative essential for biochemical research and pharmaceutical development. This compound serves as a critical substrate and regulator in enzymatic studies, particularly those involving kinases, polymerases, and metabolic pathways. It is primarily utilized by researchers and manufacturers in the life sciences, biotechnology, and diagnostic reagent industries for applications requiring precise molecular interaction and signaling.

Application

• Enzymology Research: As a substrate for studies involving guanylate kinases, nucleoside-diphosphate kinases, and other phosphotransferases.
• Cell Signaling Studies: Investigation of G-protein coupled receptor pathways and intracellular second messenger systems.
• Diagnostic Reagent Formulation: A key component in enzymatic assay kits for clinical diagnostics and high-throughput screening.
• Biochemical Synthesis: Used as a precursor or building block in the synthesis of modified nucleotides and oligonucleotides.
• Metabolic Pathway Analysis: Essential for in vitro studies of purine and pyrimidine metabolism, energy transfer, and nucleic acid biosynthesis.
• Pharmaceutical Development: Employed in drug discovery programs targeting nucleotide-binding proteins and enzymes.

Basic Information

Product Name	Guanosine 5'-Diphosphate Tris Salt
CAS No.	103192-39-8
Molecular Formula	C10H16N5O11P2 · xC4H11NO3
Molecular Weight	443.20 (Free acid) + Tris component
Synonyms	GDP Tris Salt; Guanosine-5'-diphosphate tris salt; 5'-GDP Tris Salt; Tris guanosine diphosphate; Guanosine diphosphate tris(hydroxymethyl)aminomethane salt; Guanine riboside diphosphate Tris salt; P1-(5'-Guanosyl)-P2-diphosphate Tris salt
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Diphosphate Tris Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and stringent tests for identity, moisture, and endotoxin levels where applicable. Certificates of Analysis (COA) detailing all specifications are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.5 - 8.5
Endotoxin (LAL)	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.