Description

n-tert-Butyloxycarbonyl-Prolyl-Glycyl-Alanyl-Methylamide is a protected tripeptide derivative featuring a Boc-protected N-terminus and a C-terminal methylamide. This compound is a crucial synthetic intermediate in the development of peptide-based pharmaceuticals and biochemical research tools. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for constructing more complex peptide sequences and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and proteomics research to investigate protease activity and specificity.
• Drug Discovery: Serves as a core scaffold in medicinal chemistry programs for developing novel bioactive compounds targeting various diseases.
• Fine Chemical Synthesis: Employed in the custom synthesis of specialized peptides for diagnostic kits, affinity chromatography ligands, and cosmetic active ingredients.

Basic Information

Product Name	n-tert-Butyloxycarbonyl-Prolyl-Glycyl-Alanyl-Methylamide
CAS No.	103137-94-6
Molecular Formula	C19H32N4O6
Molecular Weight	412.48 g/mol
Synonyms	Boc-Pro-Gly-Ala-NHMe; Boc-Pro-Gly-Ala-Methylamide; N-(tert-Butoxycarbonyl)-L-prolylglycyl-L-alanine methylamide; (S)-2-((S)-2-((S)-1-((tert-Butoxycarbonyl)pyrrolidine-2-carboxamido)acetamido)propanamido)propanoic acid methylamide; tert-Butyl (2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxo-1-pyrrolidine-2-carboxylate; Boc-L-Pro-Gly-L-Ala-NH-CH3
EINECS	Contact for details

Quality Control

Our n-tert-Butyloxycarbonyl-Prolyl-Glycyl-Alanyl-Methylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.