Description

(6R)-Tetrahydro-L-Biopterin Sulfate is the biologically active, reduced form of the essential cofactor L-Biopterin. This high-purity compound is critical for supporting enzymatic reactions involving aromatic amino acid hydroxylases, such as phenylalanine, tyrosine, and tryptophan hydroxylase. It is primarily utilized in advanced pharmaceutical research, diagnostic reagent formulation, and as a key reference standard in biochemical studies.

Application

• Pharmaceutical Research & Development: Essential cofactor for studying enzymes like phenylalanine hydroxylase (PAH) in metabolic disorder research and drug discovery.
• Diagnostic Reagents: Used as a critical component in enzymatic assays for the detection and quantification of amino acids and related metabolites.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of biopterin-related compounds and in clinical laboratories.
• Cell Culture & Biochemistry: Employed in cell culture media and in vitro studies to support nitric oxide synthase (NOS) activity and neurotransmitter synthesis pathways.
• Nutritional Science: Investigated for its role in metabolic pathways relevant to specialized nutraceutical formulations.

Basic Information

Product Name	(6R)-Tetrahydro-L-Biopterin Sulfate
CAS No.	103130-44-5
Molecular Formula	C9H15N5O3 • H2SO4
Molecular Weight	377.34 g/mol (free base: 241.25 g/mol)
Synonyms	(6R)-5,6,7,8-Tetrahydro-L-biopterin Sulfate; (6R)-BH4 Sulfate; Sapropterin Sulfate; (6R)-Tetrahydrobiopterin Sulfate; 6R-BH4 Dihydrochloride (common misnomer); (6R)-THB Sulfate; (6R)-L-Erythro-5,6,7,8-tetrahydrobiopterin Sulfate; Kuvan® (brand name for sapropterin dihydrochloride, related compound)
EINECS	Contact for details

Quality Control

Our (6R)-Tetrahydro-L-Biopterin Sulfate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the stringent requirements for research and diagnostic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R-isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.