Description

Neurokinin A-Oh is a synthetic peptide analog of the endogenous neurokinin A, a member of the tachykinin family of neuropeptides. This compound is a critical research tool for investigating the physiological and pathological roles of the neurokinin-2 (NK2) receptor in the central and peripheral nervous systems. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and gastrointestinal motility disorders.

Application

• Neuroscience Research: Used as a selective agonist or reference standard in studies of NK2 receptor signaling, neuronal excitability, and synaptic transmission.
• Pharmacological Assay Development: Serves as a key standard in high-throughput screening (HTS) and binding assays to identify and characterize novel NK2 receptor antagonists.
• Pain and Inflammation Studies: Applied in preclinical models to explore the role of tachykinins in nociception, neurogenic inflammation, and chronic pain pathways.
• Gastrointestinal Motility Research: Investigated for its effects on smooth muscle contraction and its implications in disorders like irritable bowel syndrome (IBS).
• Respiratory Function Research: Used in studies examining bronchoconstriction and airway hyperresponsiveness related to tachykinin activity.
• Biochemical Standard: Employed as a purity reference in analytical method development and validation for peptide quantification (HPLC, LC-MS).

Basic Information

Product Name	Neurokinin A-Oh
CAS No.	102989-34-4
Molecular Formula	C58H84N14O14S2
Molecular Weight	1241.5 g/mol
Synonyms	Neurokinin A (4-10); NKA (4-10); [Tyr5, D-Trp6,8, Arg9, Nle10]-Neurokinin A(4-10); H-Asp-Ser-Phe-Val-Tyr-D-Trp-Val-D-Trp-Arg-Nle-NH2; Tachykinin Fragment 4-10; NK2 Receptor Agonist (selective); Neurokinin A-Oh Peptide
EINECS	Contact for details

Quality Control

Every batch of Neurokinin A-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with Certificates of Analysis (COA) provided for each lot, detailing results for assay, purity (HPLC), and peptide content. We adhere to industry best practices for synthetic peptide production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.