Description

Substance P (6-11), Orn(6)- CAS NO 102979-72-6 is a synthetic bioactive peptide fragment derived from the neuropeptide Substance P. This specific analog, featuring an ornithine substitution at position 6, is a critical research tool for investigating neurokinin-1 (NK1) receptor interactions and signal transduction pathways. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptides for receptor binding studies, functional assays, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective ligand for studying the structure-activity relationship (SAR) of the Substance P C-terminal sequence and its binding to the NK1 receptor.
• Pharmacological Assays: Used in competitive binding assays and functional studies to characterize receptor subtypes and evaluate potential antagonists.
• Biochemical Tool: Employed in cell signaling research to understand the role of tachykinin peptides in inflammation, pain transmission, and other physiological processes.
• Drug Discovery & Development: Serves as a reference standard and key intermediate in the design and synthesis of novel neurokinin receptor-targeting compounds.
• Academic & Institutional Research: A fundamental reagent for university and institutional labs conducting advanced studies in neurobiology and peptide chemistry.

Basic Information

Product Name	Substance P (6-11), Orn(6)-
CAS No.	102979-72-6
Molecular Formula	C36H60N12O8
Molecular Weight	788.94 g/mol
Synonyms	Substance P (6-11), Orn6-Substance P (6-11); [Orn6]-Substance P (6-11); H-Phe-Phe-Gly-Leu-Orn-NH2; Arg-Pro-Lys-Pro-Gln-Orn-Phe-Phe-Gly-Leu-Met-NH2 (6-11 fragment); Neurokinin P (6-11) analog; Tachykinin peptide fragment; NK1 receptor ligand fragment.
EINECS	Contact for details

Quality Control

Every batch of Substance P (6-11), Orn(6)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by HPLC, MS, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with each shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.