Description

6-Hydroxy Doxazosin is a key pharmaceutical intermediate and metabolite of the antihypertensive agent Doxazosin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on cardiovascular drug development and bioanalytical method validation.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of Doxazosin and its derivatives.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for pharmacokinetics and drug metabolism.
• Analytical Research: Serves as a high-purity standard in HPLC, LC-MS, and other chromatographic methods for quality control and method development.
• Biochemical Research: Employed in studies investigating α-1 adrenergic receptor antagonists and their mechanisms of action.
• Impurity Profiling: Used to identify and quantify related substances in Doxazosin mesylate drug substance and finished dosage forms.

Basic Information

Product Name	6-Hydroxy Doxazosin
CAS No.	102932-26-3
Molecular Formula	C23H25N5O5
Molecular Weight	451.48 g/mol
Synonyms	6-Hydroxy Doxazosin; Doxazosin 6-Hydroxy Metabolite; UK-33274-27; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine-6-ol; 4-Amino-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-1-piperazinyl]-6,7-dimethoxyquinazolin-6-ol; UK 33274-27; UK33274-27
EINECS	Contact for details

Quality Control

Our 6-Hydroxy Doxazosin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and LC-MS, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.