Description

7-Hydroxy Doxazosin is a key pharmaceutical intermediate and an active metabolite of the antihypertensive drug Doxazosin. This compound is critical for research and development in cardiovascular pharmacology, serving as a reference standard and a precursor in analytical studies. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and quality control units involved in the synthesis and analysis of α-adrenergic blocking agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Doxazosin mesylate and related antihypertensive APIs.
• Analytical Reference Standard: Used for method development, validation, and quality control testing in pharmaceutical analysis via HPLC, LC-MS, or GC-MS.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity of Doxazosin.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of Doxazosin drug substance and finished products.
• Biochemical Research: Used in vitro studies to investigate the mechanism of action of α-1 adrenoceptor antagonists.
• Custom Synthesis: A starting material for the research-scale synthesis of novel analogues for structure-activity relationship (SAR) studies.

Basic Information

Product Name	7-Hydroxy Doxazosin
CAS No.	102932-25-2
Molecular Formula	C23H25N5O5
Molecular Weight	451.48 g/mol
Synonyms	7-Hydroxy Doxazosin; Doxazosin 7-Hydroxy Metabolite; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine, 7-Hydroxy Derivative; 7-OH-Doxazosin; UK-33274-27; 4-Amino-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-1-piperazinyl]-6,7-dimethoxyquinazolin-7-ol
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Doxazosin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.