Description

Mefenamic Acyl-B-D-Glucuronide is a major, pharmacologically relevant metabolite of the non-steroidal anti-inflammatory drug (NSAID) mefenamic acid. This compound is critical for research and development in pharmacokinetics, drug metabolism, and toxicology studies. It serves as a vital reference standard and analytical tool for scientists and quality control professionals in the pharmaceutical and biotechnology industries, enabling precise quantification and metabolic pathway elucidation.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of mefenamic acid and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, bioavailability, and excretion profiles of mefenamic acid in preclinical and clinical research.
• Bioanalytical Method Development: Used to develop and validate sensitive analytical methods (e.g., LC-MS/MS, HPLC) for therapeutic drug monitoring and bioequivalence studies.
• Toxicology and Safety Assessment: Aids in understanding the metabolic activation and potential toxicological pathways associated with mefenamic acid therapy.
• Quality Control in Manufacturing: Employed in pharmaceutical QC laboratories to ensure the purity of drug substances and to monitor for specific glucuronidated impurities.
• Academic and Institutional Research: Supports fundamental research in enzymology, specifically UDP-glucuronosyltransferase (UGT) activity and glucuronidation mechanisms.

Basic Information

Product Name	Mefenamic Acyl-B-D-Glucuronide
CAS No.	102623-18-7
Molecular Formula	C24H26NO9
Molecular Weight	472.47 g/mol
Synonyms	Mefenamic Acid Glucuronide; Mefenamic Acid Acyl Glucuronide; 2-[[(2,3-Dimethylphenyl)amino]benzoyl]oxy-β-D-glucopyranuronic Acid; Mefenamic Acid β-D-Glucuronide; N-(2,3-Dimethylphenyl)anthranilic Acid Glucuronide; Mefenamic Acid 1-O-Acyl-β-D-Glucuronide; Mefenamic Acid Acyl-β-D-Glucuronide; Mefenamic Acid Acyl Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Our Mefenamic Acyl-B-D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment (HPLC) and structural confirmation (NMR, MS), to ensure it meets the high standards required for reference material applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.