Description

Ciprofibrate-o-β-Glucuronide is a key metabolite of the lipid-regulating agent ciprofibrate, formed via glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development and regulatory submission support.

Application

• Pharmacokinetic and Metabolism Studies: Used as a critical reference standard to quantify and characterize the metabolic profile of ciprofibrate in biological matrices.
• Bioanalytical Method Development: Serves as a primary standard for calibrating HPLC, LC-MS, and LC-MS/MS systems in method validation for drug and metabolite assays.
• Drug Safety and Toxicology Assessment: Employed in studies to understand the excretion pathways and potential long-term effects of ciprofibrate therapy.
• Regulatory Compliance and Documentation: Essential for generating reliable data to meet FDA, EMA, and other global regulatory requirements for drug approval.
• Comparative Bioavailability/Bioequivalence Studies: Acts as a benchmark for analyzing metabolite levels in generic drug development.
• Academic and Clinical Research: Supports fundamental research into fibrate drugs' mechanisms of action and individual metabolic variability.

Basic Information

Product Name	Ciprofibrate-o-β-Glucuronide
CAS No.	102623-15-4
Molecular Formula	C23H30O10
Molecular Weight	466.48 g/mol
Synonyms	Ciprofibrate O-β-D-Glucuronide; Ciprofibrate Glucuronide; 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid β-D-glucopyranosiduronic acid; 1-(2-{4-[(2,2-Dichlorocyclopropyl)methyl]phenoxy}-2-methylpropanoyl)-β-D-glucopyranuronic acid; Ciprofibrate Metabolite; Ciprofibrate 1-O-β-Acylglucuronide
EINECS	Contact for details

Quality Control

Our Ciprofibrate-o-β-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.