Description

Bumetanide β-D-Glucuronide is a major, pharmacologically relevant metabolite of the loop diuretic bumetanide. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a high-purity reference standard for scientists and quality control professionals in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Reference Standard: Primary use as an authentic standard for the quantification of bumetanide and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and bioavailability of bumetanide.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS assays for clinical and preclinical studies.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the accuracy and reliability of analytical procedures for drug substance and product testing.
• Toxicology Research: Applied in studies assessing the safety profile and potential drug-drug interactions related to bumetanide therapy.
• Regulatory Submissions: Supports data packages for regulatory filings (e.g., with FDA, EMA) requiring characterization of drug metabolites.

Basic Information

Product Name	Bumetanide β-D-Glucuronide
CAS No.	102623-14-3
Molecular Formula	C₂₀H₂₈N₂O₁₁S
Molecular Weight	504.51 g/mol
Synonyms	Bumetanide Glucuronide; Bumetanide β-D-Glucopyranosiduronic Acid; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic Acid β-D-Glucuronide; Bumetanide 1-O-β-Glucuronide; Bumetanide O-β-D-Glucuronide; Bumetanide Metabolite M1; Bumetanide-M1; 1-O-(3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoyl)-β-D-glucopyranuronic Acid
EINECS	Contact for details

Quality Control

Our Bumetanide β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.