Description

Prepropeptide Gla, Frog is a specialized peptide sequence derived from the frog species, serving as a precursor to Gla (γ-carboxyglutamic acid) containing proteins. This compound is of significant value in biochemical and pharmaceutical research for studying the vitamin K-dependent carboxylation process and the structure-function relationships of Gla proteins. It is primarily utilized by research institutions and biotechnology companies focused on bone metabolism, blood coagulation pathways, and cardiovascular research.

Application

• Biochemical Research: Used as a model substrate to study the enzymatic mechanism of vitamin K-dependent γ-glutamyl carboxylase.
• Pharmaceutical Development: Serves as a reference standard or starting material in the development of therapeutics targeting coagulation disorders or vascular calcification.
• Proteomics & Structural Biology: Employed in mass spectrometry and NMR studies to understand the post-translational modification and 3D structure of Gla domains.
• In-vitro Diagnostics (IVD): May be used in the development of assay kits for detecting or quantifying factors involved in bone or blood metabolism.
• Academic Research: Facilitates fundamental studies in comparative endocrinology and evolutionary biology of calcium-binding proteins.
• Peptide Synthesis & Conjugation: Acts as a key intermediate or template for the chemical synthesis of modified peptide analogs for functional studies.

Basic Information

Product Name	Prepropeptide Gla, Frog
CAS No.	102619-51-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Frog Prepropeptide Gla; Gla Precursor Peptide (Frog); γ-Carboxyglutamic Acid Precursor Peptide; Vitamin K-Dependent Peptide Precursor; Prepro-Gla Protein Fragment; Bone Gla Protein (BGP) Precursor Analog; Osteocalcin Precursor Peptide (Frog)
EINECS	Contact for details

Quality Control

Our Prepropeptide Gla, Frog is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.