Description

Biotin-β-Amyloid (1-42) is a biotinylated derivative of the amyloid-beta peptide, a key protein fragment associated with Alzheimer's disease research. This modified peptide is crucial for detection and isolation applications due to the high-affinity binding of biotin to streptavidin or avidin. It is primarily utilized by researchers and diagnostic developers in the fields of neuroscience, biochemistry, and molecular biology. The compound, with CAS number 102577-21-9, serves as an essential tool for studying protein aggregation and developing diagnostic assays.

Application

• Biomarker Research & Development: Used as a tagged antigen in the development of immunoassays and biosensors for detecting amyloid-beta peptides.
• Protein-Protein Interaction Studies: Facilitates the pull-down and isolation of interacting proteins or antibodies using streptavidin-coated beads.
• Neurodegenerative Disease Modeling: Employed in in vitro and cellular studies to investigate the aggregation kinetics and toxicity of amyloid-beta (1-42).
• Diagnostic Kit Manufacturing: Integrated as a critical component in ELISA kits and other diagnostic platforms for Alzheimer's disease research.
• Drug Discovery Screening: Serves as a target for high-throughput screening of compounds designed to inhibit amyloid-beta aggregation.
• Histology & Imaging: Enables the visualization and localization of amyloid-beta plaques in tissue samples when conjugated with fluorescent streptavidin.

Basic Information

Product Name	Biotin-β-Amyloid (1-42)
CAS No.	102577-21-9
Molecular Formula	C207H317N55O58S
Molecular Weight	4514.2 g/mol
Synonyms	Biotin-Aβ(1-42); Biotin-Amyloid β-Protein (1-42); Biotin-Aβ42; Biotinylated Amyloid Beta Peptide (1-42); Biotin-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Biotin-conjugated Aβ42; Aβ1-42-Biotin; Biotinyl-Amyloid β (1-42)
EINECS	Contact for details

Quality Control

Our Biotin-β-Amyloid (1-42) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and MS for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solubility are provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Molecular Weight	4514.2 ± 2 Da
Solubility	Soluble in DMSO or dilute aqueous ammonia
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.