Description

Hemoglobin Himeji is a stable, naturally occurring variant of human hemoglobin, identified by the CAS registry number 102576-76-1. This protein is of significant scientific and diagnostic interest due to its unique structural properties that provide insights into hemoglobin function and stability. It serves as a critical reference material and research tool for professionals in clinical diagnostics, biochemical research, and pharmaceutical development who require high-purity, well-characterized hemoglobin derivatives.

Application

• Clinical Reference Standard: Used as a calibrator and control material in diagnostic assays for hemoglobinopathies and thalassemias.
• Biochemical Research: Serves as a model protein for studying oxygen-binding kinetics, protein stability, and the effects of genetic mutations.
• Hematology Studies: Essential for comparative studies on hemoglobin structure-function relationships and disease mechanisms.
• Pharmaceutical Development: Acts as a reference compound in the research and quality control of blood-based therapeutics and oxygen carriers.
• Educational Tool: Utilized in academic and laboratory training settings to demonstrate protein analysis techniques and genetic variation.

Basic Information

Product Name	Hemoglobin Himeji
CAS No.	102576-76-1
Molecular Formula	C2952H4664N812O832S40Fe4
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hb Himeji; Hemoglobin variant Himeji; HBB p.Asn139Lys; Hemoglobin β139 Asn→Lys; Hemoglobin with substitution at β139 position; Unstable hemoglobin Himeji; Hb Hij
EINECS	Contact for details

Quality Control

Our Hemoglobin Himeji is produced and handled under strict quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, electrophoresis, and spectrophotometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be prepared under aseptic conditions and stored at 2-8°C for short-term use; avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Color	Brownish-red
Identification (IR / HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Spectrophotometric)	≥ 90% of theoretical heme content
Solubility	Soluble in aqueous buffers, clear solution
Residual Moisture (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.