Description

Sulfosuccinimidyl (4-Azidophenyldithio)Propionate is a heterobifunctional crosslinking reagent designed for advanced bioconjugation and protein labeling. This compound matters for its ability to introduce cleavable disulfide bonds and photo-activatable aryl azide groups, enabling controlled and reversible linkage of biomolecules. It is primarily needed by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and the creation of functionalized surfaces for biosensors and diagnostic assays.

Application

• Controlled bioconjugation for the synthesis of antibody-drug conjugates (ADCs) with cleavable linkers.
• Site-specific photoaffinity labeling of proteins and other biomolecules for interaction studies.
• Immobilization of biomolecules onto solid supports (e.g., chips, beads) with a cleavable, light-sensitive tether.
• Introduction of reversible crosslinks in protein structure-function analysis.
• Surface functionalization for biosensor and microarray development.
• Preparation of cleavable protein-protein or protein-nucleic acid complexes.
• Proteomics research, including the study of protein complexes and interactions.

Basic Information

Product Name	Sulfosuccinimidyl (4-Azidophenyldithio)Propionate
CAS No.	102568-45-6
Molecular Formula	C17H16N4O6S2
Molecular Weight	436.46 g/mol
Synonyms	Sulfo-SADP; N-Succinimidyl-3-[(2-pyridyldithio)-4-azidobenzamido]propionate, sulfonated; 3-({4-Azido-2-[(2-pyridinyldithio)ethyl]benzoyl}amino)propanoic acid N-hydroxysuccinimide ester, sulfonated; Sulfosuccinimidyl 3-((4-azido-2-((2-pyridinyldithio)ethyl)benzamido)propanoate; SADP, sulfo-; Heterobifunctional crosslinker SADP (sulfo); NHS ester-aryl azide crosslinker (sulfo, cleavable); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Sulfosuccinimidyl (4-Azidophenyldithio)Propionate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and relevant physical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in water, DMSO, DMF
Extinction Coefficient	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.